Spontaneous regression of pulmonary pure ground-glass opacity with progression of a solid component during a 40-month follow-up

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Nobuaki Ochi
Nagio Takigawa *
Masayuki Yasugi
Daijiro Harada
Hiromichi Yamane
Mitsune Tanimoto
Katsuyuki Kiura
(*) Corresponding Author:
Nagio Takigawa | ntakigaw@gmail.com

Abstract

A 75-year-old man with a 50 pack-year smoking history underwent a right upper lobectomy due to an early stage lung adenocarcinoma. Simultaneously, pure ground-glass opacity (GGO) on the left upper lobe measuring 6.7 mm in diameter was detected on computed tomography (CT), which was considered atypical adenomatous hyperplasia, a bronchioloalveolar carcinoma, or focal organizing pneumonia/fibrosis. Eighteen months later, the diameter of the lesion increased to 9.0 mm. The lesion further enlarged to 10.4 mm with a small solid component within the GGO at 28 months after the initial CT scan. At the 33- month follow-up, the lesion had decreased in size and a solid component was prominent. Forty months after the initial CT, the lesion seemed to be a fibrotic scar. To the best of our knowledge, no studies have reported a pure GGO progressing with a solid component that regressed spontaneously over such a long period. Although this case seems rare, physicians should be aware that a lung nodule compatible with progression from in situ carcinoma to invasive carcinoma on CT could resolve over 24 months.

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Author Biographies

Nobuaki Ochi, Department of General Internal Medicine 4, Kawasaki Hospital, Kawasaki Medical School

Department of General Internal Medicine 4, Kawasaki Hospital

Nagio Takigawa, Department of General Internal Medicine 4, Kawasaki Hospital, Kawasaki Medical School

Department of General Internal Medicine 4, Kawasaki Hospital

Masayuki Yasugi, Department of General Internal Medicine 4, Kawasaki Hospital, Kawasaki Medical School

Department of General Internal Medicine 4, Kawasaki Hospital

Daijiro Harada, Department of Respiratory Medicine, Okayama University Hospital

Department of Respiratory Medicine

Hiromichi Yamane, Department of General Internal Medicine 4, Kawasaki Hospital, Kawasaki Medical School

Department of General Internal Medicine 4, Kawasaki Hospital

Mitsune Tanimoto, Department of Respiratory Medicine, Okayama University Hospital

Department of Respiratory Medicine

Katsuyuki Kiura, Department of Respiratory Medicine, Okayama University Hospital

Department of Respiratory Medicine