Two cases of monoclonal nodular pulmonary amyloidosis and review of the literature


Submitted: 18 April 2016
Accepted: 28 June 2016
Published: 21 December 2016
Abstract Views: 1052
PDF: 377
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Authors

  • Kendal M. Endicott Division of Cardiothoracic Surgery, Veterans Affairs Medical Center, Washington, DC, United States.
  • Conor F. Hynes Division of Cardiothoracic Surgery, Veterans Affairs Medical Center, Washington, DC, United States.
  • Cindy M. Hsieh Department of Pathology, The George Washington University, Washington, DC, United States.
  • Edina Paal Department of Pathology, The George Washington University, Washington, DC; Pathology and Laboratory Medicine Service, Veterans Affairs Medical Center, Washington, DC, United States.
  • Gregory Trachiotis Division of Cardiothoracic Surgery, Veterans Affairs Medical Center, Washington, DC; Division of Cardiothoracic Surgery, The George Washington University, Washington, DC, United States.
Nodular pulmonary amyloidosis (NPA) is an uncommon pathology of insoluble protein depositing in pulmonary parenchyma. This localized pulmonary form of amyloidosis is most often found to contain combinations of kappa and lambda immunoglobulin light chain and immunoglobulin heavy chain proteins with a polyclonal lymphoplasmacystic infiltrate. Herein we present two cases of NPA of the rarely reported monoclonal (light-chain restricted) form with review of the literature and discussion of the clinical, radiographic, and histologic features of NPA.

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Endicott, K. M., Hynes, C. F., Hsieh, C. M., Paal, E., & Trachiotis, G. (2016). Two cases of monoclonal nodular pulmonary amyloidosis and review of the literature. Chest Disease Reports, 6(1). https://doi.org/10.4081/cdr.6.5945

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