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Two cases of monoclonal nodular pulmonary amyloidosis and review of the literature

Kendal M. Endicott, Conor F. Hynes, Cindy M. Hsieh, Edina Paal, Gregory Trachiotis
  • Kendal M. Endicott
    Division of Cardiothoracic Surgery, Veterans Affairs Medical Center, Washington, DC, United States
  • Conor F. Hynes
    Division of Cardiothoracic Surgery, Veterans Affairs Medical Center, Washington, DC, United States
  • Cindy M. Hsieh
    Department of Pathology, The George Washington University, Washington, DC, United States
  • Edina Paal
    Department of Pathology, The George Washington University, Washington, DC; Pathology and Laboratory Medicine Service, Veterans Affairs Medical Center, Washington, DC, United States
  • Gregory Trachiotis
    Division of Cardiothoracic Surgery, Veterans Affairs Medical Center, Washington, DC; Division of Cardiothoracic Surgery, The George Washington University, Washington, DC, United States | gregory.trachiotis@va.gov

Abstract

Nodular pulmonary amyloidosis (NPA) is an uncommon pathology of insoluble protein depositing in pulmonary parenchyma. This localized pulmonary form of amyloidosis is most often found to contain combinations of kappa and lambda immunoglobulin light chain and immunoglobulin heavy chain proteins with a polyclonal lymphoplasmacystic infiltrate. Herein we present two cases of NPA of the rarely reported monoclonal (light-chain restricted) form with review of the literature and discussion of the clinical, radiographic, and histologic features of NPA.

Keywords

Pulmonary nodule; Amyloidosis; Immunoglobulin

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Submitted: 2016-04-18 13:12:10
Published: 2016-12-21 17:09:21
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Copyright (c) 2016 Kendal M Endicott, Conor F Hynes, Cindy M Hsieh, Edina Paal, Gregory Trachiotis

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