Two cases of monoclonal nodular pulmonary amyloidosis and review of the literature

  • Kendal M. Endicott Division of Cardiothoracic Surgery, Veterans Affairs Medical Center, Washington, DC, United States.
  • Conor F. Hynes Division of Cardiothoracic Surgery, Veterans Affairs Medical Center, Washington, DC, United States.
  • Cindy M. Hsieh Department of Pathology, The George Washington University, Washington, DC, United States.
  • Edina Paal Department of Pathology, The George Washington University, Washington, DC; Pathology and Laboratory Medicine Service, Veterans Affairs Medical Center, Washington, DC, United States.
  • Gregory Trachiotis | gregory.trachiotis@va.gov Division of Cardiothoracic Surgery, Veterans Affairs Medical Center, Washington, DC; Division of Cardiothoracic Surgery, The George Washington University, Washington, DC, United States.

Abstract

Nodular pulmonary amyloidosis (NPA) is an uncommon pathology of insoluble protein depositing in pulmonary parenchyma. This localized pulmonary form of amyloidosis is most often found to contain combinations of kappa and lambda immunoglobulin light chain and immunoglobulin heavy chain proteins with a polyclonal lymphoplasmacystic infiltrate. Herein we present two cases of NPA of the rarely reported monoclonal (light-chain restricted) form with review of the literature and discussion of the clinical, radiographic, and histologic features of NPA.

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Published
2016-12-21
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Issue
Section
Case Reports
Supporting Agencies
none
Keywords:
Pulmonary nodule, Amyloidosis, Immunoglobulin
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  • PDF: 235
How to Cite
Endicott, K., Hynes, C., Hsieh, C., Paal, E., & Trachiotis, G. (2016). Two cases of monoclonal nodular pulmonary amyloidosis and review of the literature. Chest Disease Reports, 4(1). https://doi.org/10.4081/cdr.2016.5945