Muscular dystrophies: key elements for everyday diagnosis and management

  • Alberto Palladino | Luisa.POLITANO@unina2.it Cardiomiologia e Genetica Medica - Dipartimento di Medicina Sperimentale, Napoli, Italy.
  • Gerardo Nigro Dipartimento di Cardiologia, Seconda Università di Napoli, Italy.
  • Luisa Politano Cardiomiologia e Genetica Medica - Dipartimento di Medicina Sperimentale, Napoli, Italy.

Abstract

Muscular dystrophies are a heterogeneous group of inherited disorders that share similar clinical features and dystrophic changes on muscle biopsy, associated with progressive weakness. Weakness may be noted at birth or develop in late adult life. In recent years, cardiac involvement has been observed in a growing number of genetic muscle diseases, and considerable progress has been made in understanding the relationships between disease skeletal muscle and cardiac muscle disease. This review will focus on the skeletal muscle diseases most commonly associated with cardiac complications that can be diagnosed by echocardiography, such as dystrophinopathies including Duchenne (DMD) and Becker (BMD) muscular dystrophies, cardiomyopathy of DMD/BMD carriers and X-L dilated cardiomyopathy.

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Published
2013-12-20
Info
Issue
Section
Echocardiography and Rare Diseases
Keywords:
cardiomyopathy, Duchenne muscular dystrophy, Becker muscular dystrophy, Duchenne and Becker carriers, genetics, echocardiography.
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How to Cite
Palladino, A., Nigro, G., & Politano, L. (2013). Muscular dystrophies: key elements for everyday diagnosis and management. Cardiogenetics, 3(1), e9. https://doi.org/10.4081/cardiogenetics.2013.e9