Matrix metalloproteinase 9 polymorphism and outcome after myocardial infarction

  • Sophie Rodius Laboratory of Cardiovascular Research, Centre de Recherche Public-Santé, Luxembourg, Luxembourg.
  • Guillermo Mulliert Laboratory of Cardiovascular Research, Centre de Recherche Public-Santé, Luxembourg, Luxembourg; Laboratory of Crystallography, Magnetic Resonance and Modeling, UMR UHP-CNRS 7036, Faculté des Sciences et Technologies, Nancy Université, Vandoeuvre-les-Nancy, France.
  • Francisco Azuaje Laboratory of Cardiovascular Research, Centre de Recherche Public-Santé, Luxembourg, Luxembourg.
  • Yvan Devaux Laboratory of Cardiovascular Research, Centre de Recherche Public-Santé, Luxembourg, Luxembourg.
  • Daniel R. Wagner | wagner.daniel@chl.lu Laboratory of Cardiovascular Research, Centre de Recherche Public-Santé, Luxembourg; Division of Cardiology, Centre Hospitalier, Luxembourg, Luxembourg.

Abstract

Matrix metalloproteinase 9 (MMP9) is functionally implicated in the process of infarct healing. Several genetic variation of the MMP9 gene have been described, among which the MMP9 Arg668Gln polymorphism. In the present study, we assessed whether this polymorphism influences outcome after acute myocardial infarction (MI). One thousand forty-nine patients undergoing coronary angiography were genotyped for the MMP9 Arg668Gln polymorphism by TaqMan allelic discrimination assay. This population included 154 controls, 161 patients with non ST-elevation MI (NSTEMI), 504 patients with ST-elevation MI (STEMI), and 230 patients with angina. Frequency of the MMP9 Arg668Gln polymorphism in the global population was 25.1%, and was comparable between all groups. STEMI patients had higher creatine phosphokinase (CPK), troponin T (TnT) and MMP9 plasma levels and had lower ejection fraction (EF) than NSTEMI patients. However, the polymorphism was not associated with infarct severity as determined by peak CPK and TnT levels, nor with LV remodeling and outcome as assessed by 1-month EF and NYHA class, as well as 2- year mortality. In silico molecular modeling simulations predicted that the MMP9 polymorphism may decrease MMP9 activity, but this could not be verified by plasma determinations. This study investigated for the first time the association between the MMP9 Arg668Gln polymorphism and clinical outcome after acute MI. Our results indicate that the polymorphism does not seem to be associated with clinical outcome and in particular with the development of left ventricular dysfunction and heart failure.

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Published
2011-07-12
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Original Articles
Supporting Agencies
National Fund for Research of Luxembourg, Society for Research on Cardiovascular Diseases, Ministry of Culture, Higher Education and Research of Luxembourg
Keywords:
matrix metalloproteinase 9, myocardial infarction, polymorphism, ventricular function.
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How to Cite
Rodius, S., Mulliert, G., Azuaje, F., Devaux, Y., & Wagner, D. (2011). Matrix metalloproteinase 9 polymorphism and outcome after myocardial infarction. Cardiogenetics, 1(1), e5. https://doi.org/10.4081/cardiogenetics.2011.e5