Genetics of cardiomyopathies in children

  • Matteo Vatta | mvatta@bcm.tmc.edu Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, United States.
  • Jeffrey A. Towbin The Heart Institute, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States.

Abstract

Cardiomyopathies are diseases of the heart muscle leading to heart failure and/or an increased risk of arrhythmogenic sudden cardiac death. These disorders represent a major cause of morbidity and mortality in children. In childhood forms of cardiomyopathy, genetic etiologies are frequent, but non-genetic or acquired causes, such viral infection, also play a significant role. In the last twenty years, the genetic causes of cardiomyopathies have been increasingly identified and clinical correlations are beginning to be defined. Here we present an overview of the recent advances in our understanding of the genetics of cardiomyopathies in children and what is known about the pathophysiological mechanisms underlying these gene-related forms of disease.

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Published
2011-08-17
Info
Issue
Section
Review Articles
Keywords:
sudden cardiac death, dilated cardiomyopathy, hypertrophic cardiomyopathy, left ventricular noncompaction, restrictive cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, Nav1.5, LQTS, ion channels.
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How to Cite
Vatta, M., & Towbin, J. (2011). Genetics of cardiomyopathies in children. Cardiogenetics, 1(1), e9. https://doi.org/10.4081/cardiogenetics.2011.e9