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A therapeutic genome editing primer for cardiologist

Martina Caiazza, Daniele Masarone, Giuseppe Limongelli
  • Martina Caiazza
    Department of Cardiology, Università Degli Studi Della Campania, Luigi Vanvitelli, Naples, Italy | martina.caiazza@yahoo.it
  • Daniele Masarone
    Department of Cardiology, Università Degli Studi Della Campania, Luigi Vanvitelli, Naples, Italy
  • Giuseppe Limongelli
    Department of Cardiology, Università Degli Studi Della Campania, Luigi Vanvitelli, Naples, Italy

Abstract

Genome editing, or genome engineering is a type of genetic engineering in which DNA is inserted, deleted or replaced in the genome of a living organism using engineered nucleases, or molecular scissors. Genome editing is being rapidly adopted into all fields of biomedical research, including the cardiovascular field, where it has facilitated a greater understanding of lipid metabolism, electrophysiology, cardiomyopathies, and other cardiovascular disorders, has helped to create a wider variety of cellular and animal models, and has opened the door to a new class of therapies. In this review, we discuss the applications of in vivo genome-editing therapies for cardiovascular disorder.

Keywords

Therapeutic genome editing; cardiovascular disease.

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Submitted: 2017-12-27 20:22:20
Published: 2018-05-16 11:22:47
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Copyright (c) 2018 Martina Caiazza, Daniele Masarone, Giuseppe Limongelli

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