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Restrictive cardiomyopathy and hypertrophic cardiomyopathy overlap: the importance of the phenotype

Juan Pablo Kaski, Elena Biagini, Massimo Lorenzini, Claudio Rapezzi, Perry Elliott
  • Juan Pablo Kaski
    Institute of Cardiovascular Science, University College London, UK; Inherited Cardiovascular Diseases Unit, Department of Cardiology, Great Ormond Street Hospital, London, United Kingdom | j.kaski@ucl.ac.uk
  • Elena Biagini
    Cardiovascular Department, University of Bologna, Italy
  • Massimo Lorenzini
    Cardiovascular Department, University of Bologna, Italy
  • Claudio Rapezzi
    Cardiovascular Department, University of Bologna, Italy
  • Perry Elliott
    Institute of Cardiovascular Science, University College London; The Heart Hospital, University College London Hospitals, London, United Kingdom

Abstract

Restrictive cardiomyopathy (RCM) is defined on the basis of the haemodynamic finding of restrictive ventricular physiology. However, restrictive ventricular pathophysiology is also a feature of other subtypes of cardiomyopathy, including hypertrophic cardiomyopathy (HCM). Clinically and aetiologically, there is an overlap between RCM and HCM with restrictive physiology. However, the clinical distinction between these two entities can be an important pointer towards the underlying aetiology. This review highlights the importance of the recognition of the clinical phenotype as the first step in the classification of cardiomyopathies.

Keywords

cardiomyopathy, sarcomere protein disease, classification, diastology.

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Submitted: 2012-09-03 11:21:43
Published: 2012-10-19 18:56:52
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Copyright (c) 2012 Juan Pablo Kaski, Elena Biagini, Massimo Lorenzini, Claudio Rapezzi, Perry Elliott

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
 
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