Catecholaminergic polymorphic ventricular tachycardia in 2012

  • Ineke Nederend Department of Cardiology, Heart Failure Research Center, Academic Medical Center, Amsterdam, Netherlands.
  • Christian van der Werf Department of Cardiology, Heart Failure Research Center, Academic Medical Center, Amsterdam, Netherlands.
  • Arthur A.M. Wilde | a.a.wilde@amc.uva.nl Department of Cardiology, Heart Failure Research Center, Academic Medical Center, Amsterdam, Netherlands.

Abstract

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare, potentially lethal inherited arrhythmia syndrome characterized by stress or emotion-induced ventricular arrhythmias. CPVT was first described in 1960, while the genetic basis underlying this syndrome was discovered in 2001. The past decade has seen substantial advances in understanding the pathophysiology of CPVT. In addition, significant advances have been made in elucidating clinical characteristics of CPVT patients and new treatment options have become available. Here, we review current literature on CPVT to present state-of-the-art knowledge on the subject of the genetic basis, pathophysiology, clinical presentation, diagnosis, treatment and prognosis.

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Published
2011-11-20
Supporting Agencies
ZorgOnderzoek Nederland Medische Wetenschappen (ZonMW, grant 120610013), Fondation Leducq Trans-Atlantic Network of Excellence, Preventing Sudden Death (grant 05-CVD-01)
Keywords:
catecholaminergic polymorphic ventricular tachycardia, sudden cardiac death, genetics, channelopathies.
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How to Cite
Nederend, I., van der Werf, C., & Wilde, A. (2011). Catecholaminergic polymorphic ventricular tachycardia in 2012. Cardiogenetics, 1(1s), e4. https://doi.org/10.4081/cardiogenetics.2011.s1.e4