Evaluate the Therapeutic Effect of Allicin (L-cysteine) on Clinical Presentation and Prognosis in Patients with COVID-19

  • Hosein Yaghoubian Department of Emergency Medicine, Mashhad University of Medical Sciences, Mashhad, Iran, Islamic Republic of.
  • Hossein Niktale Innovation, Technology and Entrepreneurship, Molecule of allicin (L-cysteine) with Stabilized Oxidation Capacity, Mashhad, Iran, Islamic Republic of.
  • Arash Peivandi Yazdi Lung Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran, Islamic Republic of.
  • Vahideh Ghorani Clinical Research Unit, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran, Islamic Republic of.
  • Masoud Mahdavi Rashed Akbar Children Hospital, Mashhad University of Medical Sciences, Mashhad, Iran, Islamic Republic of.
  • Amir Masoud Hashemian | HashemianAM11@gmail.com Department of Emergency Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran, Islamic Republic of.

Abstract

The antiviral effectiveness of allicin (L-cysteine) has been shown by numerous studies in both levels of clinical and animals. The aim of this study was to evaluate the therapeutic effect of allicin (L-cysteine) on clinical presentation and prognosis. In the current study, 66 patients with COVID-19 based on clinical, radiological presentations and RT-PCR results, were enrolled in two groups of placebo and allicin. In the both allicin (L-cysteine) and placebo groups (n=33 in each group), the capsules were prescribed two times a day for two weeks. Clinical signs and symptoms, blood parameters and chest CT scan were evaluated before and two weeks after treatment. The results showed that allicin (L-cysteine) could significantly impact on improvement of signs and symptoms of COVID-19 after two weeks of treatment in comparison to placebo. Allicin (L-cysteine) not only improve the clinical signs, but also ameliorate the lab and radiological data, which suggest a therapeutic effect for this agent in COVID-19. Our data suggest the therapeutic effect of allicin (L-cysteine) on COVID-19 through improvement of clinical symptoms and acceleration of the healing process.

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References

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Published
2021-06-18
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Original Articles
Keywords:
COVID-19, Allicin, chest CT, laboratory findings, clinical trial
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How to Cite
Yaghoubian, H., Niktale, H., Yazdi, A. P., Ghorani, V., Rashed, M. M., & Hashemian, A. M. (2021). Evaluate the Therapeutic Effect of Allicin (L-cysteine) on Clinical Presentation and Prognosis in Patients with COVID-19. European Journal of Translational Myology, 31(2). https://doi.org/10.4081/ejtm.2021.9518

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