Neurohypophyseal hormones and skeletal muscle: a tale of two faces

Abstract

The neurohypophyseal hormones vasopressin and oxytocin were invested, in recent years, with novel functions upon striated muscle, regulating its differentiation, trophism, and homeostasis. Recent studies highlight that these hormones not only target skeletal muscle but represent novel myokines. We discuss the possibility of exploiting the muscle hypertrophying activity of oxytocin to revert muscle atrophy, including cancer cachexia muscle wasting. Furthermore, the role of oxytocin in cardiac homeostasis and the possible role of cardiac atrophy as a concause of death in cachectic patients is discussed.

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Published
2020-04-01
Info
Issue
Section
Focus on 30 Years of Translational Mobility Medicine - Reviews
Supporting Agencies
Sapienza University
Keywords:
Vasopressin, Oxytocin, Muscle, Homeostasis
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How to Cite
Benoni, A., Renzini, A., Cavioli, G., & Adamo, S. (2020). Neurohypophyseal hormones and skeletal muscle: a tale of two faces. European Journal of Translational Myology, 30(1), 53-57. https://doi.org/10.4081/ejtm.2019.8899