Renal function in the third year among very low birth weight infants fed by supplemental proteins


Published: 9 January 2020
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Authors

  • Arash Bordbar Shahid Akbarabadi Clinical Research Development Unit, Iran University of Medical Sciences, Tehran, Iran, Islamic Republic of.
  • Azade Noroozi Vahid Shahid Akbarabadi Clinical Research Development Unit, Iran University of Medical Sciences, Tehran, Iran, Islamic Republic of.
  • Mandana Kashaki Shahid Akbarabadi Clinical Research Development Unit, Iran University of Medical Sciences, Tehran, Iran, Islamic Republic of.

Very Low Birth Weight (VLBW) infants have higher nutritional needs than term infants. Energy and protein are two important factors influencing their growth. Breastfeeding is not enough to meet VLBW infants’ needs, for this reason, complementary protein is required by them. Hence, the present study aimed at investigation of renal function among VLBW infants receiving complementary proteins. The study was conducted on two groups of intervention and control (n= 18 in each group) (Case study: VLBW infants born in Akbarabadi hospital of Tehran in 2014 2015). The intervention group includes 3-year-old children who weighting less than 1200 grams at birth and have received protein supplementation at the course of NICU hospitalization, protein was added to maternal milk when the amount of milk reaches to 100 cc/kg/day, at this time parenteral nutrition was discontinued and the volume of feeding was increased 20cc/kg/day until reached to 150-180cc/kg/day. We also added the fortifier to breast milk at this time. The fortification and the protein supplementation were stopped when the weight of the baby reached to 1500 grams. The control group was fed similar to the intervention group but had received no complementary protein . The renal function was evaluated by measuring such criteria as BUN, Cr, ALB and U/A. After data collection, a statistical analysis was performed using SPSS software Ver. 22. Following to BUN evaluation, a significant correlation was seen between BUN and received protein (p-value=0.010). However, there was no significant correlation between Cr and received protein as well as mean values of the two groups (p-value=0.0766). Similarly, an insignificant correlation was found between the two groups following to investigation of ALB (p-value=0/257), while the mean values of the two groups were similar. The both groups were also equal in U/A. The complementary protein increased the BUN with no effect on Cr, ALB and U/A, providing no impact on renal function. Therefore, complementary protein intake made no conflict in renal function.


Lin HJ, Du LZ, Ma XL, et al. Mortality and Morbidity of Extremely Low Birth Weight Infants in the Mainland of China: A Multi-center Study. Chin Med J (Engl). 2015;128(20):2743–2750. doi:10.4103/0366-6999.167312 DOI: https://doi.org/10.4103/0366-6999.167312

Morrison J, Riggs K & Rurak D. Fluoxetine during pregnancy: Impact on fetal development. Reproduction, fertility, and development. 2005; 17. 641-50. 10.1071/RD05030. DOI: https://doi.org/10.1071/RD05030

Puntis JW. Nutritional support in the premature newborn. Postgrad Med J. 2006;82(965):192–198. doi:10.1136/pgmj.2005.038109 DOI: https://doi.org/10.1136/pgmj.2005.038109

Denney L, Afeiche MC, Eldridge AL, Villalpando-Carrión S. Food Sources of Energy and Nutrients in Infants, Toddlers, and Young Children from the Mexican National Health and Nutrition Survey 2012. Nutrients. 2017;9(5):494. Published 2017 May 13. doi:10.3390/nu9050494 DOI: https://doi.org/10.3390/nu9050494

de Koning TJ. Amino acid synthesis deficiencies. J Inherit Metab Dis. 2017;40(4):609–620. doi:10.1007/s10545-017-0063-1 DOI: https://doi.org/10.1007/s10545-017-0063-1

Park SY, Kim TJ, Kim MJ. Acute hyperkalemia induced by hyperglycemia in non-diabetic patient. Korean J Anesthesiol. 2011;61(2):175–176. doi:10.4097/kjae.2011.61.2.175 DOI: https://doi.org/10.4097/kjae.2011.61.2.175

Underwood MA. Human milk for the premature infant. Pediatr Clin North Am. 2013;60(1):189–207. doi:10.1016/j.pcl.2012.09.008 DOI: https://doi.org/10.1016/j.pcl.2012.09.008

Behrman RE , Kliegman RM , Jenson HB , Nelson text book of pediatrics,19th ed .Philadelphia: WB Saunders , 2011

Hair AB, Hawthorne KM ,Chetta KE, Abrams SA. Human milk feeding supports adequate growth grams birth weight. BMC Res Notes .2013 Nov13, 6:459.

Yigit S, Akgoz A,Memisoglu A, Akata D, Ziegler EE. Breast milk fortification: effect on gastric emptying . J Matern Fetal Neonatal Med. 2008 Nov: 21(11): 843-6. DOI: https://doi.org/10.1080/14767050802287176

Alan S, Atasay B , Cakir U,Yildiz D, Kilic A, Kahvecioglu D, Erdeve O, Arsan S. An intention to achieve better postnatal in-hospital-growth for preterm infants: Adjustable protein fortification of human milk. Early Hum Dev. 2013 Dec; 89 (12): 1017-23. DOI: https://doi.org/10.1016/j.earlhumdev.2013.08.015

Embleton ND, Simmer K. Practice of parenteral nutrition in VLBW and ELBW infants. World Rev Nutr Diet. 2014;110:177-89. DOI: https://doi.org/10.1159/000358466

Biasini A , Marvulli L , Neri E , China M, Stella M, Monti F. Growth andeneurological outcome in ELBW preterms fed with human milk and extra-protein supplementation as routine practice : do we need further evidence J Matern Fetal Neonatal Med.2012 oct , 25 suppl 4:72-4 DOI: https://doi.org/10.3109/14767058.2012.715032

Kashaki, M., Mazouri, A., Bordbar, A., Saboute, M., Behnamfar, Z., Talebi, A. Effect of Protein Supplementation on the Growth of Infants Weighing Less than 1,000 Grams Hospitalized on the Neonatal Intensive Care Unit of Akbar Abadi Hospital in Tehran, Iran (2015-2016). Iranian Journal of Neonatology IJN, 2018; 9(3): 49-56. doi: 10.22038/ijn.2018.27558.1368

Hay WW Jr. Nutritional Support Strategies for the Preterm Infant in the Neonatal Intensive Care Unit. Pediatr Gastroenterol Hepatol Nutr. 2018;21(4):234–247. doi:10.5223/pghn.2018.21.4.234 DOI: https://doi.org/10.5223/pghn.2018.21.4.234

Morgan C, McGowan P, Herwitker S, Hart AE, Turner MA. Postnatal head growth in preterm infants: a randomized controlled parenteral nutrition study. Pediatrics (2014) 133:e120–8.10.1542/peds.2013-2207

Kumar P, Sundaram V. Protein Supplementation of Human Milk for Promoting Growth in Preterm Infants. (2011). Cochrane Review No. CD000433.

Ken Nagaya ,Shinya Tanaka ,Hiroyuki Kitajima,Masanori Fujimura. The corrected blood urea nitrogen predicts the developmental quotient of extremely low-birth-weight infants at the corrected age of 36 months. Early Human Development .2007 May,vol.83(5):285-291.

P G Radmacher, S L Lewis & D H Adamkin. Early amino acids and the metabolic response of ELBW infants (1000 g) in three time periods. Journal of Perinatology volume 29, pages 433–437 (2009) DOI: https://doi.org/10.1038/jp.2009.36

Stritzke, Amelie & Thomas, Sumesh & Amin, Harish & Fusch, Christoph & Lodha, Abhay. (2017). Renal consequences of preterm birth. Molecular and Cellular Pediatrics. 4. 10.1186/s40348-016-0068-0. DOI: https://doi.org/10.1186/s40348-016-0068-0

Seki M, Nakayama M, Sakoh T, et al. Blood urea nitrogen is independently associated with renal outcomes in Japanese patients with stage 3-5 chronic kidney disease: a prospective observational study. BMC Nephrol. 2019;20(1):115. Published 2019 Apr 2. doi:10.1186/s12882-019-1306-1 DOI: https://doi.org/10.1186/s12882-019-1306-1

Gowda S, Desai PB, Kulkarni SS, Hull VV, Math AA, Vernekar SN. Markers of renal function tests. N Am J Med Sci. 2010;2(4):170–173.

Joshua Lang, Ronit Katz, Joachim H Ix, Orlando M Gutierrez, Carmen A Peralta, Chirag R Parikh, Suzanne Satterfield, Snezana Petrovic, Prasad Devarajan, Michael Bennett, Linda F Fried, Steven R Cummings, Mark J Sarnak, Michael G Shlipak, Association of serum albumin levels with kidney function decline and incident chronic kidney disease in elders, Nephrology Dialysis Transplantation, Volume 33, Issue 6, June 2018, Pages 986–992, https://doi.org/10.1093/ndt/gfx229 DOI: https://doi.org/10.1093/ndt/gfx229

Delanghe J, Speeckaert M. Preanalytical requirements of urinalysis. Biochem Med (Zagreb). 2014;24(1):89–104. Published 2014 Feb 15. doi:10.11613/BM.2014.011 DOI: https://doi.org/10.11613/BM.2014.011

Mandana Kashaki, Fatemeh Masoudi Samghabadi, Arash Bordbar. Effect of Fortification of Breast Milk in Conjugation with Protein Supplement on Neurodevelopment of Preterm Low Birth Weight Infants at 3 Years. Med Arch. 2019 OCT; 73(5): 344-350 DOI: https://doi.org/10.5455/medarh.2019.73.344-350

Bordbar, A., Vahid, A. N., & Kashaki, M. (2020). Renal function in the third year among very low birth weight infants fed by supplemental proteins. European Journal of Translational Myology, 30(2), 304–310. https://doi.org/10.4081/ejtm.2020.8720

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