Dermal papillae flattening of thigh skin in Conus Cauda Syndrome

  • Barbara Ravara | barbara.ravara@unipd.it Interdepartmental Research Center of Myology, Department of Biomedical Science, University of Padova; A and C M-C Foundation for Translational Myology, Padova, Italy. http://orcid.org/0000-0002-0159-3245
  • Christian Hofer Ludwig Boltzmann Institute of Electrical Stimulation and Physical Rehabilitation, Vienna, Austria.
  • Helmut Kern Ludwig Boltzmann Institute of Electrical Stimulation and Physical Rehabilitation, Vienna; Physiko- und Rheumatherapie, St. Poelten, Austria.
  • Diego Guidolin Interdepartmental Research Center of Myology, Department of Neuroscience, Section of Human Anatomy, University of Padova, Italy.
  • Andrea Porzionato Interdepartmental Research Center of Myology, Department of Neuroscience, Section of Human Anatomy, University of Padova, Italy.
  • Raffaele De Caro Interdepartmental Research Center of Myology, Department of Neuroscience, Section of Human Anatomy, University of Padova, Italy.
  • Giovanna Albertin Interdepartmental Research Center of Myology, Department of Neuroscience, Section of Human Anatomy, University of Padova, Italy.

Abstract

Our previous studies have shown that severely atrophic Quadriceps muscles of spinal cord injury (SCI) persons suffering with complete conus and cauda equina syndrome, and thus with permanent denervation-induced atrophy and degeneration of muscle, were almost completely rescued to normal size after two years of home based Functional Electrical Stimulation (hbFES). Since large surface electrodes were used to stimulate the denervated thigh muscles, we wanted to know if the skin was affected by this peculiar long-term treatment. Indeed, we demonstrated by two approaches that the epidermis decreases in thickness in the long term denervated persons, while it increased to almost pre-SCI values in hbFES compliant SCI persons. Here we report data of morphometry of skin biopsies from both legs of 18 SCI persons, harvested at enrolment in the Project RISE, to test if the Interdigitation Index, a simple measurement of the epidermal‐dermal junction, may provide a further precise quantitative evidence of the flattening of the skin in those SCI persons. The Interdigitation Index of the 36 skin biopsies shows a higly significant linear correlation with the years of SCI (p < 0.001). Furthermore, when the 18 SCI persons are divided in two groups (1 to 3.9 versus 4.1 to 8.0 years from SCI, respectively) and the data are compared, the later Group presents a statistically significant -22% decrease (p, 0.029) of the Interdigitation Index. On the other hand counting the papille do not provide the same strong evidence. In conclusion, the Interdigitation Index is an additional sound quantitative structural biomarker of skin atrophy and flattening occurring in SCI. The result correlates with the much severe extent of atrophy of the permanently denervated thigh muscles, as determined at both macro and microscopic levels.We are confident that the Interdigitation Index will provide sound evidence that the effects of hbFES, we previously reported on skeletal muscle and epidermis thickness, will be extended to the dermal layer of the skin, suggesting a coordinated negative effects of SCI on skeletal muscle and skin, and an improvement of both tissues after hbFES. Incoming analyses will be extended to basal lamina, collagene types, elastic fibers and skin annexes in the subcutaneous layer.

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Published
2018-12-13
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Original Articles
Keywords:
spinal cord injury, denervated-degenerating muscle, h-b FES induced recovery, skin biopsy, Skin morphometry, Interdigitation Index
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How to Cite
Ravara, B., Hofer, C., Kern, H., Guidolin, D., Porzionato, A., De Caro, R., & Albertin, G. (2018). Dermal papillae flattening of thigh skin in Conus Cauda Syndrome. European Journal of Translational Myology, 28(4). https://doi.org/10.4081/ejtm.2018.7914

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