Two years of Functional Electrical Stimulation by large surface electrodes for denervated muscles improve skin epidermis in SCI

Abstract

Our previous studies have shown that severely atrophic Quadriceps muscles of spinal cord injury (SCI) patients suffering with complete conus and cauda equina lesions, and thus with permanent denervation-induced atrophy and degeneration of muscle fibers, were almost completely rescued to normal size after two years of home-based Functional Electrical Stimulation (h-bFES). Since we used large surface electrodes to stimulate the thigh muscles, we wanted to know if the skin was affected by long-term treatment. Here we report preliminary data of morphometry of skin biopsies harvested from legs of 3 SCI patients before and after two years of h-bFES to determine the total area of epidermis in transverse skin sections. By this approach we support our recently published results obtained randomly measuring skin thickness in the same biopsies after H-E stain. The skin biopsies data of three subjects, taken together, present indeed a statistically significant 30% increase in the area of the epidermis after two years of h-bFES. In conclusion, we confirm a long term positive modulation of electrostimulated epidermis, that correlates with the impressive improvements of the FES-induced muscle strength and bulk, and of the size of the muscle fibers after 2-years of h-bFES.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.
Published
2018-03-06
Info
Issue
Section
Rapid Reports
Supporting Agencies
The support of the European Regional Development Fund-Cross Border Cooperation Program SLOVAKIA–AUSTRIA (Interreg- Iva) project ‘Mobilität im Alter’ MOBIL N_00033, Austrian Federal Ministry of Science and Research, Ludwig Boltzmann Society (Vienna) is gra
Keywords:
spinal cord injury, denervated-degenerating muscle, long-term effects, h-bFES, skin biopsy, morphometry of epidermis
Statistics
  • Abstract views: 602

  • PDF: 255
  • HTML: 87
How to Cite
Albertin, G., Kern, H., Hofer, C., Guidolin, D., Porzionato, A., Rambaldo, A., De Caro, R., Piccione, F., Marcante, A., & Zampieri, S. (2018). Two years of Functional Electrical Stimulation by large surface electrodes for denervated muscles improve skin epidermis in SCI. European Journal of Translational Myology, 28(1). https://doi.org/10.4081/ejtm.2018.7373

Most read articles by the same author(s)