Of faeces and sweat. How much a mouse is willing to run: having a hard time measuring spontaneous physical activity in different mouse sub-strains

  • Dario Coletti | dario.coletti@uniroma1.it Sorbonne Universités, UPMC Univ Paris 06 (CNRS, UMR 8256, INSERM ERL U1164), Institut Biologie Paris-Seine, Paris, France; Dept. of Anatomy, Histology, Forensic Medicine & Orthopedics, School of Medicine Sapienza University of Rome; Interuniversity Institute of Myology, Italy. http://orcid.org/0000-0001-7373-1953
  • Sergio Adamo Dept. of Anatomy, Histology, Forensic Medicine & Orthopedics, School of Medicine Sapienza University of Rome, Italy; Interuniversity Institute of Myology, Italy.
  • Viviana Moresi Dept. of Anatomy, Histology, Forensic Medicine & Orthopedics, School of Medicine Sapienza University of Rome, Italy; Interuniversity Institute of Myology, Italy.

Abstract

Physical activity has multiple beneficial effects in the physiology and pathology of the organism. In particular, we and other groups have shown that running counteracts cancer cachexia in both humans and rodents. The latter are prone to exercise in wheel-equipped cages even at advanced stages of cachexia. However, when we wanted to replicate the experimental model routinely used at the University of Rome in a different laboratory (i.e. at Paris 6 University), we had to struggle with puzzling results due to unpredicted mouse behavior. Here we report the experience and offer the explanation underlying these apparently irreproducible results. The original data are currently used for teaching purposes in undergraduate student classes of biological sciences.

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Published
2017-03-27
Info
Issue
Section
Letters to the Editor
Supporting Agencies
ANR France, MIUR PRIN Italy, UPMC Emergence, Sapienza Ateneo
Keywords:
BALB/c mice, Murine sub-strains, Inbred mouse strains, Running behavior, Endurance exercise
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How to Cite
Coletti, D., Adamo, S., & Moresi, V. (2017). Of faeces and sweat. How much a mouse is willing to run: having a hard time measuring spontaneous physical activity in different mouse sub-strains. European Journal of Translational Myology, 27(1). https://doi.org/10.4081/ejtm.2017.6483