Denervation does not induce muscle atrophy through oxidative stress

Main Article Content

Eva Pigna
Emanuela Greco
Giulio Morozzi
Silvia Grottelli
Alessio Rotini
Alba Minelli
Stefania Fulle
Sergio Adamo *
Rosa Mancinelli
Ilaria Bellezza
Viviana Moresi
(*) Corresponding Author:
Sergio Adamo | sergio.adamo@uniroma1.it

Abstract

Denervation leads to the activation of the catabolic pathways, such as the ubiquitin-proteasome and autophagy, resulting in skeletal muscle atrophy and weakness. Furthermore, denervation induces oxidative stress in skeletal muscle, which is thought to contribute to the induction of skeletal muscle atrophy. Several muscle diseases are characterized by denervation, but the molecular pathways contributing to muscle atrophy have been only partially described. Our study delineates the kinetics of activation of oxidative stress response in skeletal muscle following denervation. Despite the denervation-dependent induction of oxidative stress in skeletal muscle, treatments with anti-oxidant drugs do not prevent the reduction of muscle mass. Our results indicate that, although oxidative stress may contribute to the activation of the response to denervation, it is not responsible by itself of oxidative damage or neurogenic muscle atrophy.

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Article Details

Author Biographies

Emanuela Greco, DAHFMO Unit of Histology and Medical Embryology, Interuniversity Institute of Myology, Sapienza University of Rome, Rome

Dip. SAIMLAL - Sezione di Istologia ed Embriologia Medica

student

Giulio Morozzi, Department of Experimental Medicine, University of Perugia, Perugia

Department of Experimental Medicine

PhD Student

Alessio Rotini, Department of Neuroscience Imaging and Clinical Sciences – Section of Physiology and Physiopathology, University “G. d’Annunzio” Chieti-Pescara, Chieti

Department of Neuroscience Imaging and Clinical Sciences – Section of Physiology and Physiopathology

PhD Student

Alba Minelli, Department of Experimental Medicine, University of Perugia, Perugia

Department of Experimental Medicine

Researcher

Stefania Fulle, Department of Neuroscience Imaging and Clinical Sciences – Section of Physiology and Physiopathology, University “G. d’Annunzio” Chieti-Pescara, Chieti

Department of Neuroscience Imaging and Clinical Sciences

Full Professor of Physiology

Sergio Adamo, DAHFMO Unit of Histology and Medical Embryology, Interuniversity Institute of Myology, Sapienza University of Rome, Rome

Dip. SAIMLAL - Sezione di Istologia ed Embriologia Medica

Full Professor of Histology & Embryology

Rosa Mancinelli, Department of Neuroscience Imaging and Clinical Sciences – Section of Physiology and Physiopathology, University “G. d’Annunzio” Chieti-Pescara, Chieti

Department of Neuroscience Imaging and Clinical Sciences

Researcher

Ilaria Bellezza, Department of Experimental Medicine, University of Perugia, Perugia

Department of Experimental Medicine

Researcher

Viviana Moresi, DAHFMO Unit of Histology and Medical Embryology, Interuniversity Institute of Myology, Sapienza University of Rome, Rome

Dip. SAIMLAL - Sezione di Istologia ed Embriologia Medica

Researcher