Observation of Network Dynamics of Ryanodine Receptors on Skeletal Muscle Sarcoplasmic Reticulum Membranes

  • Hongli Hu Wadsworth Centre, New York State Department of Health, Albany, NY, United States.
  • Xing Meng | xmeng101@gmail.com Wadsworth Centre, New York State Department of Health, Albany, NY, United States.

Abstract

Rabbit muscle vesicles derived from sarcoplasmic reticulum were used as a material in studying networks of ryanodine receptors by cryo electron tomography. Three-dimensional analysis reveals the dynamical features of these networks. It was found that the connection angles were rotated along the transmembrane axis of ryanodine receptors. Majority of the connections was observed at domains 6/6 of ryanodine receptors while a small group of connections were showed at domains 9/10. The flexible rotation and connection shift seem to facilitate the extension of an annular network on the wall of the sarcoplasmic reticulum in a triad.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.
Published
2016-06-13
Info
Issue
Section
Original Articles
Supporting Agencies
NIH
Keywords:
Muscle, Network dynamics, Ryanodine receptors, Sarcoplasmic reticulum
Statistics
  • Abstract views: 919

  • PDF: 510
  • HTML: 398
How to Cite
Hu, H., & Meng, X. (2016). Observation of Network Dynamics of Ryanodine Receptors on Skeletal Muscle Sarcoplasmic Reticulum Membranes. European Journal of Translational Myology, 26(2). https://doi.org/10.4081/ejtm.2016.5805