TY - JOUR AU - Perletti, Gianpaolo AU - Magri, Vittorio AU - Cai, Tommaso AU - Stamatiou, Konstantinos AU - Trinchieri, Alberto AU - Montanari, Emanuele PY - 2018/06/30 Y2 - 2024/03/28 TI - Resistance of uropathogens to antibacterial agents: Emerging threats, trends and treatments JF - Archivio Italiano di Urologia e Andrologia JA - Arch Ital Urol Androl VL - 90 IS - 2 SE - Reviews DO - 10.4081/aiua.2018.2.85 UR - https://www.pagepressjournals.org/aiua/article/view/aiua.2018.2.85 SP - 85-96 AB - Urinary tract infections are among the most common infectious diseases in humans. Today, resistance to nearly all antimicrobial classes is dramatically growing, and extremely drug-resistant or even pan-drug resistant pathogens are increasingly isolated around the world. It is foreseen that in the next decades the world will be facing a major medical emergency generated by the rapid spread of pathogens carrying resistance determinants of unprecedented power. Carbapenemase-producing Enterobacteriaceae, multidrug- resistant Enterococci and fluoroquinolone resistance determinants in both Gram-negative and Gram-positive uropathogens are among the greatest emergencies. In this article, the major emerging threats of particular interest to urologists are reviewed, worldwide resistance trends are illustrated, and novel and older – but still active – recommended drugs are summarized. ER -