TY - JOUR AU - Ferrara, Pietro AU - Del Vescovo, Ester AU - Ianniello, Francesca AU - Franceschini, Giulia AU - Romaniello, Luciana AU - Verrotti, Alberto PY - 2018/06/30 Y2 - 2024/03/29 TI - Desmopressin 120 mcg, 180 mcg, 240 mcg: The right treatment for the right patient JF - Archivio Italiano di Urologia e Andrologia JA - Arch Ital Urol Androl VL - 90 IS - 2 SE - Original Papers - Incontinence & Urodynamics DO - 10.4081/aiua.2018.2.127 UR - https://www.pagepressjournals.org/aiua/article/view/aiua.2018.2.127 SP - 127-129 AB - Background: The first-line drug therapy for patients with nocturnal enuresis (NE) associated with nocturnal polyuria and normal bladder function is desmopressin (dDAVP). Objective: To evaluate if increasing dose of oral desmopressin lyophilisate (MELT) can improve response rates to dDAVP and is useful in enuretic children. <br />Materials and methods: We enrolled a total of 260 children all diagnosed with NE. Enuretic children were treated with increasing MELT at a dose of 120, 180 and 240 mcg a day.<br />Results. We included in our study a total of 237 children, 164 males (69.2%) and 73 females (30.8%) aged between 5 and 18 years (mean age 10.32 ± 2.52 years). Of the 237 patients enrolled in the study and treated with MELT 120 mcg, a full response was achieved in 135 (56.9%). A partial response was achieved in 21 (8.9%) patients, therefore the dose was increased up to 180 mcg, with further improving symptoms (14.3%) or full response (9.5%), and up to 240 mcg, without usefulness. <br />Conclusions: MELT at the dose of 120 mcg resulted efficacy and safety; the increased dose up to 180 mcg resulted poorly efficacy; finally, the further increase up to 240 mcg did not improve the symptoms with the increased risk of side effects. ER -