@article{Labairu-Huerta_Padilla-Fernández_Arrondo-Arrondo_Valverde-Martínez_Martín-Rodríguez_Silva-Abuín_García-Cenador_Mirón-Canelo_Lorenzo-Gómez_2015, title={PDE-5 inhibitors in monotherapy versus combination therapy in a sample of 1200 patients with erectile dysfunction}, volume={87}, url={https://www.pagepressjournals.org/aiua/article/view/aiua.2015.3.204}, DOI={10.4081/aiua.2015.3.204}, abstractNote={Objectives: To compare the effectiveness in the treatment of erectile dysfunction when using PDE-5 inhibitors (PDE5i), alprostadil (PG-E1) and testosterone (TES) in monotherapy or combination therapy. Material and Methods: Observational multicentre retrospective study of men diagnosed and treated for ED between January 2008 and January 2014. Age, social and employment situation, pathological medical history, risk factors, usual treatments, IIEF-5 at the first consultation and at first and each 6 months follow-ups, physical examination, calculated total and free testosterone and received treatment were analysed. Descriptive statistics, one-way ANOVA analysis, Chi2 for qualitative data, t-test, Fisher’s exact test and Pearson’s correlation coefficient were used; p < 0.05 is considered significant. Results: Average age was 58.61 years, SD5.02, average follow- up time 48.21 months, SD 6.21, range 6-174 months. Out of the patients 76.12% were married, 9.81% divorced/separated, 10.04% single, 4.03% widowed; 85.14% of the total in stable partnership but 66.16% were not accompanied by their partners. In total 844 patients received monotherapy (597 PDE5i; 62 PG-E1; 36 TES; 27 penile prosthesis; 121 psychotherapy/alternative therapies) and 357 combination therapy (167 PDE5i+TES; 124 PDE5i+PGE1; 66 PG-E1+TES). There was a homogeneous distribution between risk factors and medical history groups. Satisfactory response according to IIEF-5 was achieved for 72.33% of patients on PDE5i monotherapy, 46.65% of patients on PDE5i+PG-E1 combination therapy and 83.41% of patients on PDE5i+TES. Conclusions: The best therapeutic success for ED in this series was achieved through a combination of testosterone+PDE-5 inhibitors without increasing morbidity and maintaining the response over time. Larger studies with longer follow-up will corroborate these findings.}, number={3}, journal={Archivio Italiano di Urologia e Andrologia}, author={Labairu-Huerta, Luis and Padilla-Fernández, Bárbara and Arrondo-Arrondo, José Luis and Valverde-Martínez, Lauro Sebastián and Martín-Rodríguez, Agustín and Silva-Abuín, Juan Miguel and García-Cenador, María Begoña and Mirón-Canelo, José Antonio and Lorenzo-Gómez, María Fernanda}, year={2015}, month={Sep.}, pages={204–209} }