Green tea catechins for chemoprevention of prostate cancer in patients with histologically-proven HG-PIN or ASAP. Concise review and meta-analysis

  • Gianpaolo Perletti | gianpaolo.perletti@uninsubria.it Department of Biotechnology and Life Sciences, Section of Medical and Surgical Sciences, University of Insubria, Varese, Italy; Department of Human Structure and Repair, Faculty of Medicine and Medical Sciences, Ghent University, Belgium.
  • Vittorio Magri ASST Nord Milano, Milan, Italy.
  • Anne Vral Department of Human Structure and Repair, Faculty of Medicine and Medical Sciences, Ghent University, Belgium.
  • Konstantinos Stamatiou Department of Urology, Tzaneio Hospital, Piraeus, Greece.
  • Alberto Trinchieri Urology Unit, Manzoni Hospital, Lecco, Italy.

Abstract

A focused, single outcome meta-analysis on the protective role of extracts of green tea catechins against prostate cancer. Randomized, placebo-controlled studies enrolling patients with a histologically confirmed diagnosis of high-grade Prostate Intraepithelial Neoplasia or Atypical Small Acinar proliferation but no prostate cancer were included. Meta-analysis for binary data was performed using Mantel-Haenszel statistics, using a random-effects model. Heterogeneity was investigated by calculating the I2. Four studies matched the inclusion criteria for the review. The pooled population was 223 patients; 114 and 109 patients were randomized to catechin and placebo groups, respectively. Nine cases of prstate cancer occurred in the catechin arm (7.9%), and 24 cases were reported in the placebo arm (22%). Pooled analysis resulted in a significant reduction of cancer risk in favor of the catechin arm (risk-ratio = 0.41; 95% CI: 0.19- 0.86; I2 = 0). In conclusion, our data suggest that the intake of concentrated green tea catechin preparations may confer a significant protective effect to carriers of early neoplastic lesions in the prostate. The quality of the evidence is moderate, and additional, largescale studies are warranted to substantiate these preliminary findings.

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Published
2019-10-02
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Section
Original Papers - Prostate
Keywords:
Green tea, Prostate cancer, Prostate, Polyphenols, Catechins, Epigallocatechin-3-gallate
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How to Cite
Perletti, G., Magri, V., Vral, A., Stamatiou, K., & Trinchieri, A. (2019). Green tea catechins for chemoprevention of prostate cancer in patients with histologically-proven HG-PIN or ASAP. Concise review and meta-analysis. Archivio Italiano Di Urologia E Andrologia, 91(3). https://doi.org/10.4081/aiua.2019.3.153

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