Malignant solitary fibrous tumor of urinary bladder: A rare clinical entity

  • Zisis Kratiras | zkratiras@gmail.com Department of Urology, Hippokratio General Hospital of Athens; Department of Pathology, Hippokratio General Hospital of Athens; Department of Urology, General Hospital of Volos, Greece.
  • Vasileios Spapis Department of Urology, Hippokratio General Hospital of Athens, Greece.
  • Efthymios Koniaris Department of Pathology, Hippokratio General Hospital of Athens, Greece.
  • Diomidis Kozyrakis Department of Urology, General Hospital of Volos, Greece.
  • Konstantinos Skriapas Department of Urology, General Hospital of Larisa, Greece.

Abstract

Solitary Fibrous Tumors (SFTs) are mesenchymal tumors occurring in several sites. Urinary bladder SFTs are quite rare. Eighteen cases are described in the literature and only two of them had malignant features. SFTs comprise a histologic spectrum of mesenchymal neoplasms that show fibroblastic differentiation. The signs and symptoms are non specific. Immunohistochemistry plays a pivotal role in the diagnosis, differentiating SFTs from other spindle cell mesenchymal tumors. Malignant criteria are considered the large size, increased mitotic activity, focal necrosis or hemorrhage, nuclear atypia, hypercellularity and infiltrative margins. Clinical and biological behavior of bladder SFTs is usually not aggressive but cannot be safely predicted based on the pathologic features. Complete surgical resection is the cornerstone of treatment. We present the third bladder SFT case with malignant features and a mini literature review.

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Published
2019-07-02
Info
Issue
Section
Case Reports
Keywords:
Solitary fibrous tumor, Hemangiopericytoma, Bladder tumors, Mesenchymal tumors
Statistics
  • Abstract views: 537

  • PDF: 233
How to Cite
Kratiras, Z., Spapis, V., Koniaris, E., Kozyrakis, D., & Skriapas, K. (2019). Malignant solitary fibrous tumor of urinary bladder: A rare clinical entity. Archivio Italiano Di Urologia E Andrologia, 91(2). https://doi.org/10.4081/aiua.2019.2.135