Effect of variant histology presence and squamous differentiation on oncological results and patient’s survival after radical cystectomy
Submitted: March 26, 2018
Accepted: May 7, 2018
Published: September 30, 2018
Accepted: May 7, 2018
Abstract Views: 936
PDF: 463
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Materials and methods: Data from 146 patients with radical cystectomy performed due to muscle-invasive urothelial carcinoma between January 2006 to November 2016 at our clinic were investigated. The preoperative and postoperative data of patients with variant histology were compared with nonvariant urothelial carcinoma patients. Then of patients with variant histology only those with squamous differentiation (SqD) were compared with nonvariant urothelial carcinoma patients in terms of preoperative, postoperative and survival data.
Results: Of the 146 patients, 23 had carcinoma with variant histology. Of these, 17 had SqD, 4 had glandular differentiation, 1 patient had plasmocytoid variant and 1 patient had sarcomatoid variant. In patients with variant histology, postoperative T stage and upstaging was higher, with no difference observed in terms of overall and cancer-specific survival compared with nonvariant urothelial cancer patients. SqD patients were observed to have higher postoperative T stage compared to nonvariant urothelial cancer patients, with no significant difference observed in terms of survival.
Conclusions: In cystectomy pathologies, patients with variant histology (especially SqD patients) were observed to have proportionally higher T stage compared to nonvariant urothelial carcinoma; however there were no significant differences for overall survival and cancer-specific survival.
Sefik, E., Celik, S., Basmaci, I., Yarımoglu, S., Bozkurt, I. H., Yonguc, T., & Gunlusoy, B. (2018). Effect of variant histology presence and squamous differentiation on oncological results and patient’s survival after radical cystectomy. Archivio Italiano Di Urologia E Andrologia, 90(3), 172–175. https://doi.org/10.4081/aiua.2018.3.172
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