Resistance of uropathogens to antibacterial agents: Emerging threats, trends and treatments

  • Gianpaolo Perletti | gianpaolo.perletti@uninsubria.it Department of Biotechnology and Life Sciences, Section of Medical and Surgical Sciences, Università degli Studi dell'Insubria, Varese, Italy; Faculty of Medicine and Medical Sciences, Ghent University, Ghent, Belgium.
  • Vittorio Magri Urology Secondary Care Clinic, ASST-Nord, Milan, Italy.
  • Tommaso Cai Department of Urology, Santa Chiara Regional Hospital, Trento, Italy.
  • Konstantinos Stamatiou Department of Urology, Tzaneio General Hospital of Piraeus, Piraeus, Greece.
  • Alberto Trinchieri Urology Unit, A. Manzoni Hospital, Lecco, Italy.
  • Emanuele Montanari Department of Urology, University of Milan - Ca' Granda Foundation - Ospedale Maggiore Policlinico, Milan, Italy.

Abstract

Urinary tract infections are among the most common infectious diseases in humans. Today, resistance to nearly all antimicrobial classes is dramatically growing, and extremely drug-resistant or even pan-drug resistant pathogens are increasingly isolated around the world. It is foreseen that in the next decades the world will be facing a major medical emergency generated by the rapid spread of pathogens carrying resistance determinants of unprecedented power. Carbapenemase-producing Enterobacteriaceae, multidrug- resistant Enterococci and fluoroquinolone resistance determinants in both Gram-negative and Gram-positive uropathogens are among the greatest emergencies. In this article, the major emerging threats of particular interest to urologists are reviewed, worldwide resistance trends are illustrated, and novel and older – but still active – recommended drugs are summarized.

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Published
2018-06-30
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Issue
Section
Reviews
Keywords:
Urinary tract infections, Resistance, Antibacterial agents, Antibiotics, Carbapenemase, Carbapenem resistance
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How to Cite
Perletti, G., Magri, V., Cai, T., Stamatiou, K., Trinchieri, A., & Montanari, E. (2018). Resistance of uropathogens to antibacterial agents: Emerging threats, trends and treatments. Archivio Italiano Di Urologia E Andrologia, 90(2), 85-96. https://doi.org/10.4081/aiua.2018.2.85

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