Desmopressin 120 mcg, 180 mcg, 240 mcg: The right treatment for the right patient

  • Pietro Ferrara | pietro.ferrara@unicatt.it Institute of Pediatrics, Catholic University Medical School, Rome; Campus Bio-Medico University, Rome, Italy. http://orcid.org/0000-0001-9449-3464
  • Ester Del Vescovo Campus Bio-Medico University, Rome, Italy.
  • Francesca Ianniello Institute of Pediatrics, Catholic University Medical School, Rome, Italy.
  • Giulia Franceschini Campus Bio-Medico University, Rome, Italy.
  • Luciana Romaniello San Carlo Hospital, Potenza, Italy.
  • Alberto Verrotti Department of Pediatrics, University of L’Aquila, L’Aquila, Italy.

Abstract

Background: The first-line drug therapy for patients with nocturnal enuresis (NE) associated with nocturnal polyuria and normal bladder function is desmopressin (dDAVP). Objective: To evaluate if increasing dose of oral desmopressin lyophilisate (MELT) can improve response rates to dDAVP and is useful in enuretic children.
Materials and methods: We enrolled a total of 260 children all diagnosed with NE. Enuretic children were treated with increasing MELT at a dose of 120, 180 and 240 mcg a day.
Results. We included in our study a total of 237 children, 164 males (69.2%) and 73 females (30.8%) aged between 5 and 18 years (mean age 10.32 ± 2.52 years). Of the 237 patients enrolled in the study and treated with MELT 120 mcg, a full response was achieved in 135 (56.9%). A partial response was achieved in 21 (8.9%) patients, therefore the dose was increased up to 180 mcg, with further improving symptoms (14.3%) or full response (9.5%), and up to 240 mcg, without usefulness.
Conclusions: MELT at the dose of 120 mcg resulted efficacy and safety; the increased dose up to 180 mcg resulted poorly efficacy; finally, the further increase up to 240 mcg did not improve the symptoms with the increased risk of side effects.

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Published
2018-06-30
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Section
Original Papers - Incontinence & Urodynamics
Keywords:
Desmopressin, Nocturnal enuresis
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How to Cite
Ferrara, P., Del Vescovo, E., Ianniello, F., Franceschini, G., Romaniello, L., & Verrotti, A. (2018). Desmopressin 120 mcg, 180 mcg, 240 mcg: The right treatment for the right patient. Archivio Italiano Di Urologia E Andrologia, 90(2), 127-129. https://doi.org/10.4081/aiua.2018.2.127