Evaluation of Tl-201 SPECT imaging findings in prostate cancer


Submitted: July 6, 2015
Accepted: July 6, 2015
Published: July 7, 2015
Abstract Views: 1713
PDF: 676
SUPPLEMENTARY MATERIAL: 542
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Authors

  • Sinem Ozyurt Dr. Sami Ulus Training and Research Hospital, Department of Nuclear Medicine, Van, Turkey.
  • Gokhan Koca Ankara Training and Research Hospital, Department of Nuclear Medicine, Ankara, Turkey.
  • Akif Diri Ankara Training and Research Hospital, Department of Urology, Ankara, Turkey.
  • Koray Demirel Ankara Training and Research Hospital, Department of Nuclear Medicine, Ankara, Turkey.
  • Tolga Karakan Ankara Training and Research Hospital, Department of Urology, Ankara, Turkey.
  • Berkan Resorlu Ankara Training and Research Hospital, Department of Urology, Ankara, Turkey.
  • Meliha Korkmaz Ankara Training and Research Hospital, Department of Nuclear Medicine, Ankara, Turkey.
  • Cankon Germiyanoglu Ankara Training and Research Hospital, Department of Urology, Ankara, Turkey.
Objectives: To compare with histopathological findings the findings of prostate cancer imaging by SPECT method using Tl-201 as a tumor seeking agent.
Methods: The study comprised 59 patients (age range 51-79 years, mean age 65.3 ± 6.8 years) who were planned to have transrectal ultrasonography (TRUS)-guided biopsies due to suspicion of prostate cancer between April 2011 and September 2011. Early planar, late planar and SPECT images were obtained for all patients. Scintigraphic evaluation was made in relation to uptake presence and patterns in the visual assessment and to Tumor/Background (T/Bg) ratios for both planar and SPECT images in the quantitative assessment. Histopathological findings were compatible with benign etiology in 36 (61%) patients and malign etiology in 23 (39%) patients. Additionally, comparisons were made to evaluate the relationships between uptake patterns,total PSA values and Gleason scores.
Results: A statistically significant difference was found between the benign and malignant groups in terms of uptake in planar and SPECT images and T/Bg ratios and PSA values. No statistically significant difference was found between uptake patterns of planar and SPECT images and Gleason scores in the malignant group.
Conclusions: SPECT images were superior to planar images in the comparative assessment. Tl-201 SPECT imaging can provide an additional contribution to clinical practice in the diagnosis of prostate cancer and it can be used in selected patients.

Ozyurt, S., Koca, G., Diri, A., Demirel, K., Karakan, T., Resorlu, B., Korkmaz, M., & Germiyanoglu, C. (2015). Evaluation of Tl-201 SPECT imaging findings in prostate cancer. Archivio Italiano Di Urologia E Andrologia, 87(2), 147–150. https://doi.org/10.4081/aiua.2015.2.147

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