Results of tadalafil treatment in patients following an open nerve-sparing radical prostatectomy

  • Erkan Hirik | ehirik@gmail.com Erzincan University Mengücek Gazi Education and Research Hospital, Urology Clinic, Turkey.
  • Aliseydi Bozkurt Erzincan University Mengücek Gazi Education and Research Hospital, Urology Clinic, Turkey.
  • Mehmet Karabakan Erzincan University Mengücek Gazi Education and Research Hospital, Urology Clinic, Turkey.
  • Özkan Onuk Gaziosmanpasa Taksim Education and Research Hospital, Urology Clinic, Turkey.
  • Mustafa Bahadır Can Balcı Gaziosmanpasa Taksim Education and Research Hospital, Urology Clinic, Turkey.
  • Memduh Aydın Gaziosmanpasa Taksim Education and Research Hospital, Urology Clinic, Turkey.
  • Murat Çakan Erzincan University Mengücek Gazi Education and Research Hospital, Urology Clinic, Turkey.
  • Barıs Nuhoglu Erzincan University Mengücek Gazi Education and Research Hospital, Urology Clinic, Turkey.

Abstract

Purpose: To evaluate the effect of postoperatively administering a low daily dose of tadalafil on the erectile function of patients who underwent a nerve-sparing radical prostatectomy(NSRP) due to localized prostate cancer (PCa). Materials and Methods: Of 138 patients, who underwent NSRP due to PCa between 2012 and 2014, 55 patients who had not had pre-operative erectile dysfunction (ED) were included in the study. The mean age of the patients was 64 (54-72). On the 15th day after surgery, after ultrasound evaluation, all 55 patients started on a daily dose of 5 mg tadalafil that was continued for 2.5 months. The erectile function of patients was evaluated pre-operatively, post-operatively, and at the 3rd and 6th month after surgery using the International Index of Erectile Function (IIEF-5) test. None of the patients was treated with hormonal therapy or radiotherapy before or after surgery. Results: Three patients were excluded from the study due to the adverse effects of tadalafil and two patients elected to discontinue the treatment. Of the remaining 50 patients whose pre-operative erectile function had been found normal, at 3 months after surgery, 36 (72%) had normal erectile function; of the remaining patients in the study six (12%) presented with mild, two (4%) with moderate, and six (12%) with severe ED. Six months after surgery, 35 patients (70%) had normal erectile function while seven (14%) had mild, three (6%) moderate and five (10%) severe ED. There was no statistically significant difference between the results obtained at the 3rd and 6thmonth follow-up (p > 0.05). Three patients reported adverse effects with tadalafil including flushes in 2 (3.6%) and a headache in 1 (1.8%). Conclusions: The administration of a 5 mg post-operative dose of tadalafil to patients that had undergone a bilateral NSRP was found to have a positive effect on the recovery and maintenance of erectile function. However, there is still a need to investigate a larger series of cases.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.
Published
2016-03-31
Info
Issue
Section
Original Papers - Prostate
Keywords:
Radical prostatectomy, Tadalafil, Erectile function
Statistics
  • Abstract views: 2212

  • PDF: 1125
How to Cite
Hirik, E., Bozkurt, A., Karabakan, M., Onuk, Özkan, Balcı, M., Aydın, M., Çakan, M., & Nuhoglu, B. (2016). Results of tadalafil treatment in patients following an open nerve-sparing radical prostatectomy. Archivio Italiano Di Urologia E Andrologia, 88(1), 4-6. https://doi.org/10.4081/aiua.2016.1.4