Role of phytotherapy associated with antibiotic prophylaxis in female patients with recurrent urinary tract infections

  • Emanuela Frumenzio | emanuela.frumenzio@virgilio.it Clinica Urologica e Andrologica di Perugia, Università degli Studi di Perugia, Italy.
  • Daniele Maglia Clinica Urologica e Andrologica di Perugia, Università degli Studi di Perugia, Italy.
  • Eleonora Salvini Clinica Urologica e Andrologica di Perugia, Università degli Studi di Perugia, Italy.
  • Silvia Giovannozzi Clinica Urologica e Andrologica di Perugia, Università degli Studi di Perugia, Italy.
  • Manuel Di Biase Clinica Urologica e Andrologica di Perugia, Università degli Studi di Perugia, Italy.
  • Vittorio Bini Clinica Urologica e Andrologica di Perugia, Università degli Studi di Perugia, Italy.
  • Elisabetta Costantini Clinica Urologica e Andrologica di Perugia, Università degli Studi di Perugia, Italy.

Abstract

Objective: Aim of this study is to evaluate the efficacy of a phytotherapic which includes Solidago, Orthosiphon and Birch extract (Cistimev®) in association with antibiotic prophylaxis in female patients affected by recurrent urinary tract infections (UTIr). Materials and methods: Patients affected by UTIr older than 18 years started a 3-months antibiotic prophylaxis (Prulifloxacin 600 mg, 1 cps/week or Phosphomicyn 1 cachet/week) according to antibiogram after urine culture. The patients were divided in 2 groups: Group A: antibiotic prophylaxis plus phytotherapy (1 cps/die for 3 months) and Group B: antibiotic prophylaxis alone. Results: 164 consecutive patients were studied: 107 were included in group A (mean age 59 ± 17.3 years) and 57 (mean age 61 ± 15.7) in group B. During the treatment period the relapse frequencies between the two groups were not significantly different (p = 0.854): 12/107 (11.21%) patients interrupted the treatment for UTIr in group A and 6/57 (10.52%) in group B. In the long term follow-up the relapse UTI risk was significant different in the two groups with a relapse risk 2.5 greater in group B than in group A (p < 0.0001). Conclusion: Our study demonstrated that in female patients affected by recurrent UTI, the association between antibiotic prophylaxis and of a phytotherapic which includes Solidago, Orthosiphon and Birch extract reduced the number of UTI in the 12 months following the end of prophylaxis and obtained a longer relapsing time, greatly improving the quality of life of the patients.

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Published
2013-12-31
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Section
Original Papers - Urogynecology
Keywords:
Recurrent urinary infection, Phytotherapy, Antibiotc prophylaxis
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How to Cite
Frumenzio, E., Maglia, D., Salvini, E., Giovannozzi, S., Di Biase, M., Bini, V., & Costantini, E. (2013). Role of phytotherapy associated with antibiotic prophylaxis in female patients with recurrent urinary tract infections. Archivio Italiano Di Urologia E Andrologia, 85(4), 197-199. https://doi.org/10.4081/aiua.2013.4.197