Impact of long-term and short-term therapies on seminal parameters

  • Jlenia Elia Department of Clinical and Molecular Medicine, Sant’Andrea Hospital, Unit of Andrology, University of Rome “Sapienza”, Rome, Italy.
  • Norina Imbrogno Department of Clinical and Molecular Medicine, Sant’Andrea Hospital, Unit of Andrology, University of Rome “Sapienza”, Rome, Italy.
  • Michele Delfino Department of Clinical and Molecular Medicine, Sant’Andrea Hospital, Unit of Andrology, University of Rome “Sapienza”, Rome, Italy.
  • Rossella Mazzilli Department of Clinical and Molecular Medicine, Sant’Andrea Hospital, Unit of Andrology, University of Rome “Sapienza”, Rome, Italy.
  • Vincenzo Spinosa Department of Clinical and Molecular Medicine, Sant’Andrea Hospital, Unit of Andrology, University of Rome “Sapienza”, Rome, Italy.
  • Fernando Mazzilli | fernando.mazzilli@uniroma1.it Department of Clinical and Molecular Medicine, Sant’Andrea Hospital, Unit of Andrology, University of Rome “Sapienza”, Rome, Italy.

Abstract

Aim: The aim of this work was: i) to evaluate the prevalence of male partners of subfertile couples being treated with long/short term therapies for non andrological diseases; ii) to study their seminal profile for the possible effects of their treatments on spermatogenesis and/or epididymal maturation. Methods: The study group was made up of 723 subjects, aged between 25 and 47 years. Semen analysis was performed according to World Health Organization (WHO) guidelines (1999). The Superimposed Image Analysis System (SIAS), which is based on the computerized superimposition of spermatozoa images, was used to assess sperm motility parameters. Results: The prevalence of subjects taking pharmacological treatments was 22.7% (164/723). The prevalence was 3.7% (27/723) for the Short-Term Group and 18.9% (137/723) for the Long-Term Group. The subjects of each group were also subdivided into subgroups according to the treatments being received. Regarding the seminal profile, we did not observe a significant difference between the Long-Term, Short-Term or the Control Group. However, regarding the subgroups, we found a significant decrease in sperm number and progressive motility percentage in the subjects receiving treatment with antihypertensive drugs compared with the other subgroups and the Control Group. Conclusions: In the management of infertile couples, the potential negative impact on seminal parameters of any drugs being taken as Long-Term Therapy should be considered. The pathogenic mechanism needs to be clarified.

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Published
2013-04-19
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Section
Original Papers - Andrology
Keywords:
Male fertility, Semen, Long-Term Therapy, Short-Term Therapy
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How to Cite
Elia, J., Imbrogno, N., Delfino, M., Mazzilli, R., Spinosa, V., & Mazzilli, F. (2013). Impact of long-term and short-term therapies on seminal parameters. Archivio Italiano Di Urologia E Andrologia, 85(1), 20-23. https://doi.org/10.4081/aiua.2013.1.20