In many parts of the world, research, improved technology, and better medicine have enabled people with thalassemia to live longer. It is tragic that due to global disparity in healthcare, in areas of the world where thalassemia is most prevalent, the mortality rates are high, and often, patients do not survive past adolescence. Each stage of life holds different challenges for people with thalassemia, and if patients are fortunate enough to reach adulthood, then they are faced with a new set of challenges uncommon to pediatric patients. Providers who have dedicated their careers to improving care now must work toward helping patients achieve a high quality of adult life by addressing such struggles. However, there is one topic that affects patients and providers universally at every stage of life—implementation of the concept can be easy, and it is free: that is COMMUNICATION!