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Thalassemia Reports

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Vol 4, No 2 (2014): A tribute to Renzo Galanello and Antonio Cao

This special issue would like to be a tribute to Renzo Galanello and Antonio Cao, two very important figures in the fields of Pediatrics, Hematology and Thalassemia. With their studies, they have contributed to the growth of the whole scientific community, to the understanding of the pathophysiology and molecular basis of hemoglobinopathies and to the improvement of therapeutic interventions. Antonio Cao, an excellent clinician and an extremely curious scientist, has contributed to design various programs of population screening, genetic counseling and prenatal diagnosis that led to the substantial eradication of β-thalassemia in Sardinia, the land he was born in and loved so much. Renzo Galanello has been a leading scientist in the clinical validation of novel oral chelators and the diagnostic assessment of cardiac iron overload by nuclear magnetic resonance. Their studies provided a considerable contribution in promoting the survival, general health and quality of life of the β-thalassemia patients worldwide. They both were members of national and international scientific associations, of editorial committees of hematology journals and scientific advisors of the Thalassemia International Federation. Their careers were signed by countless honors and prizes. The several publications on their behalf continue to give starting points for the development of new lines of research. For all these reasons, Antonio and Renzo are still among us and will be forever until we will be able to understand the actuality of the teachings contained in their studies and make good use for years to come.

Prof. Aurelio Maggio,

Table of Contents


Remembrance for Prof. Antonio Cao and Prof. Renzo Galanello
Paolo Moi | DOI: 10.4081/thal.2014.3223
Obituary - In memory of Prof. Renzo Galanello
Andrea Mosca | DOI: 10.4081/thal.2014.1961

TIF's role in promoting global control of hemoglobinopathies

The role of Thalassemia International Federation in the promotion, of global, regional and national policy of control of hemoglobin disorders: a brief overview
Androulla Eleftheriou | DOI: 10.4081/thal.2014.1963
The Thalassemia International Federation: a global public health paradigm
Elpidoforos S. Soteriades, David Weatherall | DOI: 10.4081/thal.2014.1840

Clinical Studies

Iron chelating agents for iron overload diseases
Guido Crisponi, Valeria Marina Nurchi, Maria Antonietta Zoroddu | DOI: 10.4081/thal.2014.2046
Recent developments centered on orally active iron chelators
Robert Hider | DOI: 10.4081/thal.2014.2261
Role of iron metabolism genetic determinants in response to chelation therapy in a cohort of β-thalassemia and sickle cell syndromes Italian patients
Maria Concetta Renda, Disma Renda, Angela Piazza, Giuseppina Calvaruso, Emanuela Fecarotta, Antonino Giangreco, Aurelio Maggio | DOI: 10.4081/thal.2014.2729
The role of magnetic resonance imaging in the evaluation of thalassemic syndromes: current practice and future perspectives
Sophie Mavrogeni, George Markousis-Mavrogenis, Genovefa Kolovou | DOI: 10.4081/thal.2014.1859
Raman spectroscopy technology to monitor the carotenoids in skin of thalassemia patients: a novel non-invasive tool relating oxidative stress with iron burden
Anna Perrone, Luisa Tesoriere, Anna Maria Pintaudi, Alessandro Attanzio, Paolo Rigano, Aurelio Maggio, Maria Antonietta Livrea | DOI: 10.4081/thal.2014.1967
Thalassemia and the heartquake
Caterina Borgna-Pignatti, Anna Tarocco, Alessandro Baldan, Alessandro Fucili | DOI: 10.4081/thal.2014.1941

Laboratory Studies

HbA2 measurements in β-thalassemia and in other conditions
Giovanni Ivaldi, Giuseppina Barberio, Cornelis L. Harteveld, Piero Giordano | DOI: 10.4081/thal.2014.1832
Dilemmas in considering β-thalassemia status in subjects with borderline HbA2 values: a pilot study in Eastern India
Tridip Chatterjee, Amit Chakravarty, Sudipa Chakravarty | DOI: 10.4081/thal.2014.2103
Reference intervals for acetylated fetal hemoglobin in healthy newborns
Renata Paleari, Irene Mutta, Gianluca Musolino, Alessandro Salvatoni, Massimo Agosti, Gaia Francescato, Andrea Mosca | DOI: 10.4081/thal.2014.2120
Reactivation of fetal hemoglobin in thalassemia and sickle cell disease
Sandro Eridani, Francesca Avemaria, Andrea Mosca | DOI: 10.4081/thal.2014.2196
Differential regulation of plasma proteins between members of a family with homozygous HbE and HbEβ-thalassemia
Suchismita Halder, Tridip Chatterjee, Amit Chakravarty, Sudipa Chakravarty, Abhijit Chakrabarti | DOI: 10.4081/thal.2014.1837
γA gene repeats polymorphism for the analysis of haplotypes of abnormal hemoglobins
Nejat Akar, Kadir Sipahi, Ece Akar, Erkan Yilmaz | DOI: 10.4081/thal.2014.1935

Prenatal Diagnosis

Prenatal diagnosis of hemoglobinopathies: from fetoscopy to coelocentesis
Gianfranca Damiani, Margherita Vinciguerra, Cristina Jakil, Monica Cannata, Filippo Cassarà, Francesco Picciotto, Giovanna Schillaci, Valentina Cigna, Disma Renda, Aldo Volpes, Francesca Sammartano, Samuela Milone, Adolfo Allegra, Cristina Passarello, Filippo Leto, Antonino Giambona | DOI: 10.4081/thal.2014.2200
Providing appropriate genetic information to healthy multi-ethnic carriers of hemoglobinopathy in The Netherlands
Piero C. Giordano, Natasha B.D. Binda, Antonio Amato, Egbert Bakker, Cornelis L Harteveld | DOI: 10.4081/thal.2014.1822
Control of thalassemia in India
Roshan B. Colah, Ajit Gorakshakar | DOI: 10.4081/thal.2014.1955

Future Perspectives

Development and recent progresses of gene therapy for β-thalassemia
Santina Acuto, Elena Baiamonte, Rosalia Di Stefano, Barbara Spina, Rita Barone, Aurelio Maggio | DOI: 10.4081/thal.2014.2925
Development of plasmids for quantitative detection of integrated lentiviral vectors and evaluation of culture time to perform vector titer by real-time quantitative polymerase chain reaction assay
Elena Baiamonte, Mariella Bagliesi, Valentina Motta, Barbara Spina, Alice Pecoraro | DOI: 10.4081/thal.2014.2189
Preimplantation HLA typing for stem cell transplantation treatment of hemoglobinopathies
Anver Kuliev, Oleg Verlinsky, Svetlana Rechitsky | DOI: 10.4081/thal.2014.1853

Abstracts of the meeting "Time on advances in haematological disorders"

Abstract book
Scientific Coordinators: F. Pane, A. Maggio | DOI: 10.4081/thal.2014.4725

Thalassemia Reports [eISSN 2039-4365] is a new Open Access, online-only, peer-reviewed journal published by PAGEPress®, Pavia, Italy. All credits and honors to PKP for their OJS.
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