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Ultrasensitive MAPK/Erk activation in absence of protein synthesis in Xenopus oocytes
Rémy Beaujois, Franck Riquet, Katia Cailliau, Edith Browaeys-Poly, Christophe Russo, Ralf Blossey, Dorothée Vicogne, Matthieu Marin, Arlette Lescuyer-Rousseau, Jean-Pierre Vilain, Jean-François Bodart
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- Rémy Beaujois
EA 4479, Laboratoire de Régulation des Signaux de Division, University of Lille1; USR 3078 CNRS, Institut de Recherche Interdisciplinaire, Villeneuve d’Ascq, France
| jean-francois.bodart@univ-lille1.fr
- Franck Riquet
EA 4479, Laboratoire de Régulation des Signaux de Division, University of Lille1; USR 3078 CNRS, Institut de Recherche Interdisciplinaire, Villeneuve d’Ascq, France
- Katia Cailliau
EA 4479, Laboratoire de Régulation des Signaux de Division, University of Lille1, France
- Edith Browaeys-Poly
EA 4479, Laboratoire de Régulation des Signaux de Division, University of Lille1, France
- Christophe Russo
EA 4479, Laboratoire de Régulation des Signaux de Division, University of Lille1; USR 3078 CNRS, Institut de Recherche Interdisciplinaire, Villeneuve d’Ascq, France
- Ralf Blossey
USR 3078 CNRS, Institut de Recherche Interdisciplinaire, Villeneuve d’Ascq, France
- Dorothée Vicogne
USR 3078 CNRS, Institut de Recherche Interdisciplinaire, Villeneuve d’Ascq, France
- Matthieu Marin
EA 4479, Laboratoire de Régulation des Signaux de Division, University of Lille1, France
- Arlette Lescuyer-Rousseau
EA 4479, Laboratoire de Régulation des Signaux de Division, University of Lille1, France
- Jean-Pierre Vilain
EA 4479, Laboratoire de Régulation des Signaux de Division, University of Lille1, France
- Jean-François Bodart
EA 4479, Laboratoire de Régulation des Signaux de Division, University of Lille1; USR 3078 CNRS, Institut de Recherche Interdisciplinaire, Villeneuve d’Ascq, France
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Abstract
The mitogen-activated protein kinase (MAPK) cascade in Xenopus oocytes exhibits an all-or-none, ultrasensitive response, which is believed to result from a positive feed-back loop. Here we describe a context where 1,10-phenanthroline slowly, but strongly, activates MAPK while it impairs protein synthesis in a zincdependent manner, abolishing any feed-back loop. The induced-MAPK response was found to be strongly ultrasensitive. We argue that underlying this behaviour is a regulation motif akin to a feed-forward loop acting in vivo.
Keywords
MAPK, ultrasensitivity, feed-back, protein synthesis, regulation motif.
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