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Diketopiperazine from marine bacterium Pseudoalteromonas ruthenica KLPp3

Faiq Sulieman, Asmat Ahmad, Gires Usop, Lu Chung Kuang
  • Faiq Sulieman
    School of Bioscience and Biotechnology, University Kebangsaan Malaysia, Selangor, Malaysia | faiq@siswa.ukm.edu.my
  • Asmat Ahmad
    School of Bioscience and Biotechnology, University Kebangsaan Malaysia, Selangor, Malaysia
  • Gires Usop
    School of Environmental Science and Natural Resources, University Kebangsaan Malaysia, Selangor, Malaysia
  • Lu Chung Kuang
    National Research Institute of Chinese Medicine, Taipei, Taiwan, Province of China

Abstract

Sub-minimum inhibitory concentration levels of Pseudoalteromonas ruthenica KLPp3 extract showed antibiofilm activity against Vibrio alginolyticus and Serratia marcescens. The KLPp3 crude extract was fractionated by thin layer chromatography, flash chromatography, solid phase extraction and semi-preparative high performance liquid chromatography. The pure compounds were then identified using H-nuclear magnetic resonance, C-nuclear magnetic resonance, 2D-nuclear magnetic Resonance and mass spectrometry. Nine fractions were collected from purification with two active fractions. One fractions were identified belong to the family of diketopiperazine.

Keywords

Diketopiperazine; Sub-minimum inhibitory concentrations; Crude extract; Antibiofilm; Pseudoalteromonas ruthenica.

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Submitted: 2017-11-17 17:38:06
Published: 2018-05-17 13:57:44
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Copyright (c) 2018 Faiq Sulieman, Asmat Ahmad, Gires Usop, Lu Chung Kuang

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