Accuracy of serum markers, progesterone and vitamins measurements for early screening of abortions in the eastern region of Algeria (Batna)


Submitted: October 21, 2017
Accepted: December 22, 2017
Published: February 12, 2018
Abstract Views: 983
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Authors

  • Sara Mouffouk Laboratory of Biotechnology of Bioactive Molecules and Cell Physiopathology, University of Batna 2 Mustapha Benboulaid, Algeria.
  • Mouloud Yahia Laboratory of Biotechnology of Bioactive Molecules and Cell Physiopathology, University of Batna 2 Mustapha Benboulaid, Algeria.
  • Chaima Mouffouk Laboratory of Biotechnology of Bioactive Molecules and Cell Physiopathology, University of Batna 2 Mustapha Benboulaid, Algeria.
  • Hanane Boukrous Laboratory of Biochemistry, Hospital of Batna, Algeria.
  • Aicha Saaidia Obstetrics Gynecology Service, Hospital of Meriem Bouatoura-Batna, Algeria.
  • Fairouz Douha Laboratory of Biotechnology of Bioactive Molecules and Cell Physiopathology, University of Batna 2 Mustapha Benboulaid, Algeria.
  • Naima Achi Laboratory of Biochemistry, Hospital of Batna, Algeria.
Spontaneous abortion is an involuntary interruption of pregnancy before 22 weeks of gestation. According to the Algerian National Institute of Public Health the percentage of women suffering from permanent complications during pregnancy is approximately 15%. The aim of this study is the determination of some biochemical analytes, including folic acid, vitamin B12, alphafoetoproteine, beta human chorionic gonadotropin (β-hCG), progesterone and oestradiol (uE3), which are involved in the detection of pregnancy failures. This case-control study was carried out on women in the process of abortion and a control group with viable pregnancies in the East region of Algeria (Batna) during the year 2015. In the present investigation, 69 pregnant women during the first and second trimester were recruited during the first and second trimesters as cases (with miscarriages) and the control group (n=69) was constituted of women who had normal ultrasound. The average concentration of alpha-fetoprotein is significantly low during the first trimester, but it is very high during the second trimester between cases and controls. The median values of β- hCG, uE3 and progesterone decrease very significantly. The mean concentration of serum folate and vitamin B12 did not change significantly between cases and controls in the first and second trimesters. The results of this study revealed that, spontaneous abortions are associated with changes in serum markers and progesterone, which could form an important part in the early diagnosis of non-viable pregnancies. However, vitamins levels have no significant effects on these pregnancies.

Chayachinda C, Thamkhantho M, Bhuwapathanapun M, Srinilta A. Avortement septique: une expérience de 5 ans à l'hôpital Siriraj. J Med Assoc Thai 2012;95:307-12.

Costello AM, Osrin D. Micronutrient status during pregnancy and outcomes for newborn infants in developing countries. J Nut 2003;133:1757-64.

Ayoubi JM, Hirt R, Badiou W, Hininger-Favier I et al. Nutrition et femme enceinte. J Gynecol Obstet 2012;5:1-14.

Cabrol D, Pons JC, Goffinet JF. Traité d'obstétrique. Paris, Flammarion, Médecine-Sciences;2003.

Geyl C, Subtil D, Vaast P, Coulon C et al. Interprétation des valeurs atypiques des marqueurs sériques. J Gynecol Obstet Biol Reprod 2014;43:5-11.

Gordon JD, Speroff L. Handbook for clinical gynecologic endocrinology and infertility. Lippincott Williams & Wilkins; 2002.

Mobasheri E, Keshtkar A, Golalipour MJ. Maternal folate and vitamin B12 status and neural tube defects in Northern Iran: a case control study. Iran J pediatr 2010;20:167-73.

Dugoff L, Hobbins JC, Malone FD, Porter TF et al. First-trimester maternal serum PAPP-A and free-beta subunit human chorionic gonadotropin concentrations and nuchal translucency are associated with obstetric complications: a population-based screening study (the FASTER Trial). Am J Obstet Ggynecol 2004;191:1446-51.

Rissanen A, Niemimaa M, Suonpää M, Ryynänen M et al. Pregnancy-associated plasma protein A, free human chorionic gonadotrophin and nuchal translucency as predictors of miscarriage. Clin Genet 2006;69:287-9.

Yaron Y, OchshornY, Heifetz S, Lehavi O et al. First trimester maternal serum free human chorionic gonadotropin as a predictor of adverse pregnancy outcome. Fetal diagn ther 2002;17:352-6.

Bick DP, McCorkle D, Stanley WS, Stern HJ et al. Prenatal diagnosis of Smith-Lemli-Opitz syndrome in a pregnancy with low maternal serum oestriol and a sex-reversed fetus. Prenat Diagn 1999;19:68-71.

Keren DF, Canick JA, Johnson MZ, Schaldenbrand JD et al. Low maternal serum unconjugated estriol during prenatal screening as an indication of placental steroid sulfatase deficiency and X-linked ichthyosis. Am J Clin Pathol 1995;103:400-3.

Weissgerber TL, Wolfe LA. Physiological adaptation in early human pregnancy: adaptation to balance maternal-fetal demands. Appl physiol Nutr Metab 2006;31:1-11.

Cunningham DS, Brodnik RM, Rayl DL, Brown AW et al. Suboptimal progesterone production in pathologic pregnancies. J Reprod Med 1993; 38:301-5.

Daily CA, Laurent SL, Nunley WC. The prognostic value of serum progesterone and quantitative beta-human chorionic gonadotropin in early human pregnancy. Am J Obstet Gynecol 1994;171:380-3.

Muller F, Dreux S, Sault C, Galland A et al. Very low alpha-fetoprotein in down syndrome maternal serum screening. Prenat Diagn 2003; 23:584-7.

Cuckle H. Biochemical screening for Down syndrome. Eur J Obstet Gynecol Reprod Biol 2000; 92: 97-101.

Milunsky A, Jick SS, Bruell CL, MacLaughlin DS et al. Predictive values, relative risks, and overall benefits of high and low maternal serum α-fetoprotein screening in singleton pregnancies: new epidemiologic data. Am J Obstet Gynecol 1989;161:291-7.

Williams MA, Hickok DE, Zingheim RW, Luthy DA et al. Elevated maternal serum alpha-fetoprotein levels and midtrimester placental abnormalities in relation to subsequent adverse pregnancy outcomes. Am J Obstet Gynecol 1992;167: 1032-7.

Hoffman ML, Scoccia B, Kurczynski TW, Shulman LP et al. Abnormal folate metabolism as a risk factor for first-trimester spontaneous abortion. J Reprod Med 2008 ;53:207-12.

Sara Mouffouk, Laboratory of Biotechnology of Bioactive Molecules and Cell Physiopathology, University of Batna 2 Mustapha Benboulaid

Mouloud Yahia, Laboratory of Biotechnology of Bioactive Molecules and Cell Physiopathology, University of Batna 2 Mustapha Benboulaid
Professor in Cell Biology and Physiology
Chaima Mouffouk, Laboratory of Biotechnology of Bioactive Molecules and Cell Physiopathology, University of Batna 2 Mustapha Benboulaid
PhD student in biochemistry
Hanane Boukrous, Laboratory of Biochemistry, Hospital of Batna

Aicha Saaidia, Obstetrics Gynecology Service, Hospital of Meriem Bouatoura-Batna

Naima Achi, Laboratory of Biochemistry, Hospital of Batna

Supporting Agencies

Laboratory of Biotechnology of Bioactive Molecules and Cell Pathophysiology, University of Batna2(mustapha Benboulaid), Algeria, Laboratory of Biochemistry, University of Hospital of Batna (Algeria), Service of Obstetrics Gynecology of the Hospital

Mouffouk, S., Yahia, M., Mouffouk, C., Boukrous, H., Saaidia, A., Douha, F., & Achi, N. (2018). Accuracy of serum markers, progesterone and vitamins measurements for early screening of abortions in the eastern region of Algeria (Batna). Journal of Biological Research - Bollettino Della Società Italiana Di Biologia Sperimentale, 90(2). https://doi.org/10.4081/jbr.2017.7151

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