A soluble form of CTLA-4 is present in serum of pediatric patients with acute lymphoblastic leukaemia

R. Simone; C. Tenca; F. Fais; G. De Rossi; G. Pesce; M. Bagnasco; D. Saverino

doi:10.4081/jbr.2011.4665

A soluble form of CTLA-4 is present in serum of pediatric patients with acute lymphoblastic leukaemia

https://doi.org/10.4081/jbr.2011.4665

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Vol. 84 No. 1 (2011)

Submitted: August 7, 2014
Accepted: August 7, 2014

Published: January 30, 2011

soluble CTLA-4, acute lymphoblatic leukemia

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Authors

CTLA-4 can regulate and maintain self-telerance, providing a negative signal limiting immunoresponses. Acute lymphoblastic leukemia is a clonal disorder of lymphoid progenitors representing the most frequent malignancy of childhood. Here, we show the presence of significantly elevated levels of a soluble form of CTLA-4 in 70% of B-ALL patients. A possible role of this soluble molecule in the pathogenesis of this neoplastic disease can be envisaged.

Simone, R., Tenca, C., Fais, F., De Rossi, G., Pesce, G., Bagnasco, M., & Saverino, D. (2011). A soluble form of CTLA-4 is present in serum of pediatric patients with acute lymphoblastic leukaemia. Journal of Biological Research - Bollettino Della Società Italiana Di Biologia Sperimentale, 84(1). https://doi.org/10.4081/jbr.2011.4665