Antioxidant cosupplementation therapy with vitamin C, vitamin E, and coenzyme Q10 in patients with oligoasthenozoospermia


Submitted: March 28, 2014
Accepted: March 28, 2014
Published: March 28, 2014
Abstract Views: 5591
PDF: 5096
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Authors

  • Yoshitomo Kobori Department of Urology, Dokkyo Medical University, Koshigaya Hospital, Japan.
  • Shigeyuki Ota Department of Urology, Dokkyo Medical University, Koshigaya Hospital, Japan.
  • Ryo Sato Department of Urology, Dokkyo Medical University, Koshigaya Hospital, Japan.
  • Hiroshi Yagi Department of Urology, Dokkyo Medical University, Koshigaya Hospital, Japan.
  • Shigehiro Soh Department of Urology, Dokkyo Medical University, Koshigaya Hospital, Japan.
  • Gaku Arai Department of Urology, Dokkyo Medical University, Koshigaya Hospital, Japan.
  • Hiroshi Okada Department of Urology, Dokkyo Medical University, Koshigaya Hospital, Japan.
Objective: Overproduction of reactive oxygen species results in oxidative stress, a deleterious process that damages cell structure as well as lipids, proteins, and DNA. Oxidative stress plays a major role in various human diseases, such as oligoasthenozoospermia syndrome. Materials and methods: We evaluated the effectiveness of antioxidant co-supplementation therapy using vitamin C, vitamin E, and coenzyme Q10 in men with oligoasthenozoospermia. Overall, 169 infertile men with oligoasthenozoospermia received antioxidant therapy with 80 mg/day vitamin C, 40 mg/day vitamin E, and 120 mg/day coenzyme Q10. We evaluated spermiogram parameters at baseline and at 3 and 6 months of follow-up. Results: Significant improvements were evident in sperm concentration and motility following coenzyme Q10 therapy. Treatment resulted in 48 (28.4%) partner pregnancies, of which 16 (9.5%) were spontaneous. Significant improvements in sperm cell concentration and sperm motility were observed after 3 and 6 months of treatment. Conclusions: Vitamin C, vitamin E, and coenzyme Q10 supplementation resulted in a significant improvement in certain semen parameters. However, further studies are needed to empirically determine the effect of supplementation on pregnancy rate.

Kobori, Y., Ota, S., Sato, R., Yagi, H., Soh, S., Arai, G., & Okada, H. (2014). Antioxidant cosupplementation therapy with vitamin C, vitamin E, and coenzyme Q10 in patients with oligoasthenozoospermia. Archivio Italiano Di Urologia E Andrologia, 86(1), 1–4. https://doi.org/10.4081/aiua.2014.1.1

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